DERIVATIVES OF 1H-PYRAZOLO [3,4-D] PYRIMIDINE AND METHOD OF THEIR PRODUCTION Russian patent published in 2017 - IPC C07D487/04 A61K31/519 A61P31/04 

FIELD: chemistry.

SUBSTANCE: invention relates to novel derivatives of 1H-pyrazolo [3.4-d] pyrimidine of the general formula I , where: R=CH₃, R¹=C(O)NH (Ia); R=CH₃, R¹=C(NH)NH₂ (Ib); R=naphthylmethyl, R¹=C(O)NH₂ (Ic); R=naphthylmethyl, R¹=C(NH)NH₂ (Ir). Derivatives of 1H-pyrazolo[3,4-d]pyrimidine presented in the formula I, are produced by the interaction of 4,6-dichloro-2-S-(substituted) pyrimidine-5-carbaldehyde dissolved in tetragidrofurane, with the addition of the calculated derived quantities of hydrazine and triethylamine in a molar ratio of 1:1:2, the mixture is mixed on the magnetic agitator for 12 h at room temperature. The resulting precipitate is poured with water and stirred at room temperature for 3 hours. The regenerated precipitate is filtered.

EFFECT: production of new compounds that can be used for the synthesis of heterocyclic compounds and in medicine as antimicrobial agents.

2 cl, 2 tbl, 5 ex