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2 709 498

(13)

(51)

IPC

A61K31/375(2006-01-01)

A61K31/4402(2006-01-01)

A61K31/455(2006-01-01)

C07D213/55(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2018145970, 2018-12-25

(24)

Start date

2018-12-25

(22)

Actual filing date

2018-12-25

(45)

Published

2019-12-18

(72)

Inventor

Vodyankina Olga VladimirovnaEvtushenko Diana NikolaevnaSkorik Nina AlekseevnaPlotnikov Evgenij VladimirovichFateev Aleksandr Vladimirovich

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Natsionalnyj Issledovatelskij Tomskij Gosudarstvennyj Universitet Ni Tgu)

APOPTOSIS-INDUCING AGENTS AND A METHOD FOR PRODUCTION THEREOF Russian patent published in 2019 - IPC A61K31/375 A61K31/4402 A61K31/455 C07D213/55 A61P35/00

Abstract RU 2709498 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing picoline or nicotinic acid adducts with ascorbic acid, characterized in that to aqueous solution of ascorbic acid is added picolinic acid or nicotinic acid (pre-treated with microwave radiation) in molar ratio of 1:2 (C₆H₅NO₂:C₆H₈O₆) with constant stirring at room temperature, after a short stirring, a precipitate of picoline or nicotinic acid adduct with ascorbic acid is formed, which after hourly crystallisation is filtered, then the obtained adduct precipitate is washed with small portions of the solvent and dried in air.

EFFECT: disclosed are apoptosis-inducing agents and a method for production thereof.

3 cl, 1 dwg, 1 tbl, 5 ex

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RU 2 709 498 C1

Authors

Vodyankina Olga Vladimirovna

Evtushenko Diana Nikolaevna

Skorik Nina Alekseevna

Plotnikov Evgenij Vladimirovich

Fateev Aleksandr Vladimirovich

Dates

2019-12-18—Published

2018-12-25—Filed