FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology, specifically to immunogenic peptides, and can be used to reduce or block the immune response to an antigen included in the immunogenic peptide. Immunogenic peptide containing 13 to 75 amino acids containing a T-cell epitope of the antigen in a complex with MHC class II and directly adjacent or separated by not more than 7 amino acids from said epitope, and a redox motif sequence selected from the group consisting of HC-XX-[CST], HXC-XX-[CST], or H-XX-C-XX-[CST], or [CST]-XX-CH, [CST]-XX-CXH and [CST] -XX-C-XX-H, where X can be any amino acid. Obtained peptide is used to obtain antigen-specific CD4 + cytolytic T-cells in vitro.
EFFECT: invention enables reducing the immune response to said antigen, which can be used in treating autoimmune diseases.
47 cl, 1 dwg, 1 tbl, 10 ex
