NEUTRALIZING MONOCLONAL HUMAN ANTI-INTERLEUKIN-33 ANTIBODIES Russian patent published in 2019 - IPC C07K16/24 C12N15/13 C12N15/63 C12N5/10 A61K39/395 A61P37/00

Abstract RU 2709722 C1

FIELD: biotechnology.

SUBSTANCE: present invention relates to immunology. Disclosed are versions of a human neutralizing anti-IL-33 monoclonal antibody, as well as a nucleic acid coding molecule, a vector, a host cell and a method of producing said antibody variants. Invention also discloses a composition for inhibiting expression of INF-gamma, IL-5, IL-6 or IL-13 cytokines, as well as a pharmaceutical composition for treating, preventing or ameliorating diseases associated with IL-33.

EFFECT: present invention can find further application in therapy, including inflammatory diseases.

15 cl, 11 dwg, 14 tbl, 28 ex

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RU 2 709 722 C1

Authors

Fudzino Yasukhiro

Esikava Tsutomu

Oti Khirosi

Dates

2019-12-19—Published

2014-12-26—Filed