METHOD OF PRODUCING FLUORINE-SUBSTITUTED ORGANIC ALIPHATIC COMPOUND AND METHOD OF PURIFYING FLUORINE-SUBSTITUTED ORGANIC ALIPHATIC COMPOUND Russian patent published in 2019 - IPC C07C17/38 C07C17/389 C07C17/383 C07C19/08 C07C21/18 A61K51/04 A61K51/02 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a fluorine-substituted organic aliphatic compound (particularly [¹⁸F] fluoropropylcarbomethoxytropane) suitable for use as a radiopharmaceutical, including a step for reacting a fluorine salt with an aliphatic compound containing a substitutable group, using a multifunctional solvent, having chemical formula 1, to obtain an aliphatic compound labeled with [¹⁸F] fluoride. Aliphatic compound containing a substitutable group has formula N-(CH₂) n-X₂ or O-(CH₂) n-X₂, where group X₂ is a substituted group, and n is an integer in range of 1–10, and the fluorine salt is used as a source [¹⁸F] fluoride is a compound containing fluorine-18. Method can additionally include a purification step by solid-phase extraction (TFE) using an ion-exchange TFE cartridge of formula 2.

EFFECT: technical result is high efficiency of labeling, yield and purity of product.

25 cl, 2 dwg, 16 tbl, 29 ex