FLUTEMETAMOL PRODUCTION METHOD Russian patent published in 2020 - IPC C07D277/66 C07B59/00 A61K101/00 A61K101/02 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a method of producing [¹⁸F]flutemetamol, involving steps of (a) reacting a compound of general formula (1) with radioactive fluoride to obtain a reaction mixture, containing a compound represented by the following general formula (2), and a compound represented by the following general formula (1); (b) exposing the strong base to the reaction mixture obtained in step (a); (c) purifying the compound of general formula (2), after step (b) using the reversed-phase solid-phase extraction cartridge and (d) removing both protective groups to obtain [¹⁸F]flutemetamol, where R₁ is a protecting group for a hydroxy group, and C(O)R₂ is a protective group for an amino group, where R₁ and R₂ have same values as in a compound represented by general formula (1).

EFFECT: technical result is production of [¹⁸F]flutemetamol with high output.

8 cl, 1 tbl, 5 ex