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2 710 733

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(51)

IPC

C12N1/20(2006-01-01)

C12P1/06(2006-01-01)

A61P31/04(2006-01-01)

C12R1/465(2006-01-01)

(21) (22)

Application

2019120387, 2019-07-01

(24)

Start date

2019-07-01

(22)

Actual filing date

2019-07-01

(45)

Published

2020-01-10

(72)

Inventor

Lapchinskaya Olda AnastasevnaKatrukha Genrikh StepanovichPogozheva Valeriya VladimirovnaFilicheva Valentina AndreevnaKharitonova Lidiya AleksandrovnaLapchinskaya Mariya YulevnaYakovenko Alla NikolaevnaOrlova Galina IvanovnaKulyaeva Valeriya ViktorovnaPonomarenko Valerij IvanovichTyurin Anton PavlovichKorshun Vladimir Arkadevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Institut Po Izyskaniyu Novykh Antibiotikov Imeni G.F. Gauze"

STRAIN STREPTOMYCES TENDAE - PRODUCER OF ANTIBACTERIAL ANTIBIOTIC INA 5812 Russian patent published in 2020 - IPC C12N1/20 C12P1/06 A61P31/04 C12R1/465

Abstract RU 2710733 C1

FIELD: biotechnology.

SUBSTANCE: invention can be used in biotechnology for production of antibacterial agent INA 5812. Antibiotic INA 5812 according to the chemical structure is an original linear-cyclic glycopeptide compound which is active against gram-positive pathogens in vitro and highly effective in experiments in vivo in the experimental treatment of staphylococcal sepsis in white mice. Disclosed is a new strain – producer of antibiotic INA 55812 by selective transformation of properties of soil culture Streptomyces tendae. Strain is deposited in the collection of cultures of BRC VKPM SRC "Kurchatov Institute"-Genetika number VKPM Ac-1980.

EFFECT: strain Streptomyces tendae VKPM Ac-1980 has high antibiotic activity and accumulates 2,500 microgram/ml of antibacterial INA 5812 in deep cultivation.

1 cl, 2 tbl, 1 ex

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RU 2 710 733 C1

Authors

Lapchinskaya Olda Anastasevna

Katrukha Genrikh Stepanovich

Pogozheva Valeriya Vladimirovna

Filicheva Valentina Andreevna

Kharitonova Lidiya Aleksandrovna

Lapchinskaya Mariya Yulevna

Yakovenko Alla Nikolaevna

Orlova Galina Ivanovna

Kulyaeva Valeriya Viktorovna

Ponomarenko Valerij Ivanovich

Tyurin Anton Pavlovich

Korshun Vladimir Arkadevich

Dates

2020-01-10—Published

2019-07-01—Filed