FIELD: pharmacology.
SUBSTANCE: group of inventions is claimed that can be used for production of antibacterial dimethylvancomycin sulfate antibiotic, effective for treatment of infections caused by gram-positive pathogens, including methicillin-resistant and anaerobic ones. Amycolatopsis orientalis strain, the producer of dimethylvancomycin deposited in VKPM under the registration number VKPM As-1984, and a method fordimethylvancomycin production are proposed. The method for dimethylvancomycin preparation involves cultivation of the Amycolatopsis orientalis strain VKPM-As-1984, antibiotic sorption from the native solution on the KB-2 (Na+) cation exchange, antibiotic desorption, eluate neutralisation with the KU-2-20 (H+) cation exchanger and antibiotic sorption (pH 6.8) on Amberlite CG-25 (NH4+) followed by elution of dimethyl vancomycin (0.05-0.3) n. with ammonia solution. The aqueous solution of the antibiotic is concentrated and precipitated with acetone.
EFFECT: increased degree of purification.
2 cl, 2 tbl, 2 ex
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