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2 711 655

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IPC

C07D207/27(2006-01-01)

C07D207/263(2006-01-01)

C07C309/02(2006-01-01)

(21) (22)

Application

2019128788, 2019-09-13

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Start date

2019-09-13

(22)

Actual filing date

2019-09-13

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Published

2020-01-20

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Inventor

Tarasenko Dmitrij ViktorovichBoldyrev Ivan AleksandrovichKramarova Evgeniya PetrovnaBaukov Yurij IvanovichNegrebetskij Vadim VitalevichShmigol Tatyana AnatolevnaShagina Anastasiya Dmitrievna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Natsionalnyj Issledovatelskij Meditsinskij Universitet Imeni N.I. Pirogova" Ministerstva Zdravookhraneniya Rossijskoj Federatsii

METHOD FOR LARGE-SCALE SYNTHESIS OF POTASSIUM SALT OF 2-[2-(2-OXO-4-PHENYLPYRROLIDIN-1-YL)ACETAMIDO]ETHANE SULPHONIC ACID Russian patent published in 2020 - IPC C07D207/27 C07D207/263 C07C309/02

Abstract RU 2711655 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method for large-scale synthesis of potassium salt of 2-[2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamido]ethane sulphonic acid. Method comprises the following stages: a) alkylation of 4-phenylpyrrolidinone-2 to obtain ethyl ester of 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetic acid; b) hydrolysis of ethyl ether of 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetic acid to obtain free acid; c) reacting 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetic acid with N-hydroxysuccinimide to obtain N-hydroxysuccinimide ester of 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetic acid; and d) reacting 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetic acid N-hydroxysuccinimide ester with 2-aminoethanesulphonic acid and potassium hydroxide to obtain potassium salt 2-[2-(2-oxo-4-phenylpyrrolidine -1-yl)acetamido]ethanesulphonic acid.

EFFECT: disclosed method enables to carry out large-scale synthesis of the end product.

1 cl, 4 ex

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RU 2 711 655 C1

Authors

Tarasenko Dmitrij Viktorovich

Boldyrev Ivan Aleksandrovich

Kramarova Evgeniya Petrovna

Baukov Yurij Ivanovich

Negrebetskij Vadim Vitalevich

Shmigol Tatyana Anatolevna

Shagina Anastasiya Dmitrievna

Dates

2020-01-20—Published

2019-09-13—Filed