FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 2-[2-oxo-1-pyrrolidinyl] acetamide substituted at position 4 of the pyrrolidine cycle, in which R1 is H, R2 is selected from H, Ph, 2,4-diClPh, 4-ClPh, 4-CH3OPh, 3-NO2Ph; or R1 and R2 form together C5H10. The method consists in reaction of potassium salt 3-R1R2-4-aminobutyric acid with chloroacetamide in a molar ratio of 2:1 in alcoholic medium, the isolation of N-carbamoylmethyl-3-R1R2-4-aminobutyric acid by acidification, followed by its cyclization in a medium of high boiling immiscible organic solvent with a boiling point of 140 to 200°C and distillation of water. .
EFFECT: method is safe and technological, it uses available raw materials and can be used in large-scale industrial production.
2 cl, 1 tbl, 7 ex
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Authors
Dates
2017-08-24—Published
2016-06-14—Filed