FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 2-[2-oxo-1-pyrrolidinyl] acetamide substituted at position 4 of the pyrrolidine cycle, in which R1 is H, R2 is selected from H, Ph, 2,4-diClPh, 4-ClPh, 4-CH3OPh, 3-NO2Ph; or R1 and R2 form together C5H10. The method consists in reaction of potassium salt 3-R1R2-4-aminobutyric acid with chloroacetamide in a molar ratio of 2:1 in alcoholic medium, the isolation of N-carbamoylmethyl-3-R1R2-4-aminobutyric acid by acidification, followed by its cyclization in a medium of high boiling immiscible organic solvent with a boiling point of 140 to 200°C and distillation of water. 
.
EFFECT: method is safe and technological, it uses available raw materials and can be used in large-scale industrial production.
2 cl, 1 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| AMINOCARBOXYLIC ACID AMIDES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION | 1994 |
|
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| 0 |
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| N-CARBAMOYLMETHYL-4-PHENYL-2-PYRROLIDONE NEW COMPOSITION | 2017 |
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| DERIVATIVES OF IMIDAZOPYRIDINES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING | 1995 |
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| METHOD FOR LARGE-SCALE SYNTHESIS OF POTASSIUM SALT OF 2-[2-(2-OXO-4-PHENYLPYRROLIDIN-1-YL)ACETAMIDO]ETHANE SULPHONIC ACID | 2019 |
|
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| THIAZOLINONE-2-SUBSTITUTED QUINOLINES | 2005 |
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| SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE COMPOUNDS AND USE THEREOF IN DRUG PREPARATIONS (TRADEMARK GRA 3 363) | 2007 |
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