METHOD OF PRODUCING FONTURACETAM FROM PHENIBUT Russian patent published in 2024 - IPC C07D207/27 C07D209/54 

Abstract RU 2827339 C1

FIELD: chemistry; pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical chemistry, specifically to synthesis of 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide (fonturacetam) used as a nootropic. Method of producing fonturacetam from phenibut by alkylation thereof with 2-haloacetamide is characterized by that the process is carried out in water, in one chemical step, combining alkylation and cyclisation, in the presence of a weak base – an organic amine of general formula R1R2R3N, where R1, R2, R3 are alkyl, alkylidene groups, both separate from each other and forming closed cycle(s), including containing heteroatoms O, S, N.

EFFECT: safe and processable single-step method of producing the desired compound using available raw material and water as a solvent, while maintaining an acceptable output of the product.

1 cl, 1 ex

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RU 2 827 339 C1

Authors

Mukhametshin Sergej Viktorovich

Belyakov Nikolaj Grigorevich

Zhun Ilya Vladimirovich

Perevalov Valerij Pavlovich

Dates

2024-09-24Published

2024-01-11Filed