FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formula (I), where values of R1-R4 are defined in the claim, which have properties of ligands melatonin receptors MT1, MT2 and MT3 (quinone-reductase 2 enzyme) subtypes. Invention also relates to a method of producing compounds of formula (I) and pharmaceutical compositions thereof.
.
EFFECT: inventions can be used as a drug for treating and preventing ophthalmic diseases, particularly for treating glaucoma.
11 cl, 3 tbl, 18 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 2,3-DIHYDRO-1H-INDOLE DERIVATIVES HAVING PROPERTIES OF LIGANDS OF MELATONINE RECEPTORS, METHOD FOR OBTAINING AND USING | 2017 |
|
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| INDOLINONE DERIVATIVES HAVING MELATONIN RECEPTOR LIGAND PROPERTIES AND USE THEREOF | 2017 |
|
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| AMIDE-CONTAINING DERIVATIVES OF 2-OXINDOLE, METHOD FOR PRODUCTION AND APPLICATION THEREOF | 2017 |
|
RU2685501C1 |
| ARYLCYCLOALKYLAMINES DERIVATIVES NEUROPROTECTOR (VERSIONS), SUBSTANCES WITH COMBINED NEUROPROTECTOR, ANALGETIC AND ANTIDEPRESSIVE ACTION, PHARMACEUTICAL COMPOSITIONS BASED THEREON | 2016 |
|
RU2637928C2 |
| SUBSTITUTED 4-(AZOL-1-YLMETHYL)-1-PHENYL-5,5-DIALKYL-SPIRO-[2.5]OCTAN-4-OLS, METHOD FOR PRODUCTION THEREOF (VERSIONS), FUNGICIDAL AND GROWTH-REGULATING COMPOSITION BASED THEREON | 2016 |
|
RU2648240C1 |
| NOVEL 2',5'-DIARYLSPIRO[INDOLE-3,3'-PYRROLIDINE]-2(1H)-ONES AND A METHOD FOR PRODUCTION THEREOF | 2019 |
|
RU2730287C1 |
| NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS, SYNTHESIS METHODS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID INHIBITORS | 2007 |
|
RU2443687C2 |
| METHOD OF TREATING DIABETES MELLITUS | 2019 |
|
RU2734495C1 |
| USE OF 1'-ARYLDISPIRO[CYCLOALKANE-1,3'-AZETIDINE-2',3''-INDOLINE]-2'',4'-DIONES AS ANALGESICS | 2023 |
|
RU2809008C1 |
| NOVEL PHOSPHATE COMPOUNDS, SYNTHESIS METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | 2014 |
|
RU2617682C2 |
