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(19)

RU

(11)

2 712 099

(13)

C2

(51)

IPC

C07J9/00(2006-01-01)

C07J41/00(2006-01-01)

C07J43/00(2006-01-01)

A61K31/57(2006-01-01)

A61K31/575(2006-01-01)

A61K31/58(2006-01-01)

A61P1/16(2006-01-01)

A61P3/06(2006-01-01)

A61P3/10(2006-01-01)

A61P9/10(2006-01-01)

A61P13/12(2006-01-01)

(21) (22)

Application

2017134013, 2016-03-30

(24)

Start date

2016-03-30

(22)

Actual filing date

2016-03-30

(45)

Published

2020-01-24

(72)

Inventor

Veng GotsyanOr Yat SunShen ZhujchaoSin SyuechaoLun TszyanDaj PenGrejndzher BrettKhe Tszin

(73)

Holder

Enanta Farmasyutikals, Ink.

BILE ACID DERIVATIVES AS FXR/TGR5 AGONISTS AND METHODS FOR USE THEREOF Russian patent published in 2020 - IPC C07J9/00 C07J41/00 C07J43/00 A61K31/57 A61K31/575 A61K31/58 A61P1/16 A61P3/06 A61P3/10 A61P9/10 A61P13/12 

Abstract RU 2712099 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula I, or a pharmaceutically acceptable salt thereof. In formula IRa is hydrogen; Rb is -SO2R1; R2 is hydrogen; Rc is hydrogen; m is selected from 0, 1 and 2; R3 is hydrogen; R4 is hydrogen; R5 and R6 are hydrogen; R7 is unsubstituted -C1-C8 alkyl; values of other radicals are given in the patent claim. Invention also relates to individual compounds, to a method for preventing or treating an FXR-mediated disease or condition in a subject in need thereof, to a pharmaceutical composition.

EFFECT: technical result is obtaining novel compounds of formula I, having FXR modulator properties.

24 cl, 9 tbl, 218 ex

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RU 2 712 099 C2

Authors

Veng Gotsyan

Or Yat Sun

Shen Zhujchao

Sin Syuechao

Lun Tszyan

Daj Pen

Grejndzher Brett

Khe Tszin

Dates

2020-01-24—Published

2016-03-30—Filed

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