METHOD FOR PREPARING SULFONYLCARBAMATE BILE ACID DERIVATIVES Russian patent published in 2023 - IPC C07J31/00 C07J41/00 A61K31/56 

FIELD: organic chemistry.

SUBSTANCE: method for obtaining a compound of the formula (II) where the values of the substitutes of the formula (II) are given in the claims. The method includes the following steps: (1ai) CDCA esterification, (1aii) introduction of a hydroxyl-protecting group into the product (1ai) and interaction of the obtained compound with a halogenating agent, (1aiii) removal of hydrogen halide from the product (1aii), (1aiv) removal of the protective group from the product (1aiii), (1av) introduction of a hydroxyl-protecting group into the product (1aiv), (1avi) oxidative cleavage and oxidation of the product (1av), (2bi) esterification of the product (1avi), (2bii) reaction of the silylating agent with the product in the presence of a base (2bi), (2biii) interaction of a product (2bii) with acetaldehyde in the presence of a Lewis acid, (2biv) hydrogenation of the product (2biii), (2bv) interaction of a product (2biv) with a base in a protic solvent or in a mixture of protic and non-protic solvents, (2bvi) introduction of a hydroxyl-protecting group into the product (2bv), (3bi) reaction of a suitable chloroformate with the product (2bvi), (3bii) reduction of the product (3bi), (4bi) reaction of the product (3bii) with a suitable sulfonyl carbamate, (4bii) deprotecting the product (4bi) to give a compound of formula (II), wherein the structural formulas of said intermediates are given in the claims.

EFFECT: improvement of the method for obtaining the formula compound (II) by increasing the yield of the target product and reducing the process steps.

7 cl, 25 ex