NEUROACTIVE STEROIDS AND METHODS OF THEIR USE Russian patent published in 2023 - IPC C07J9/00 A61K31/575 A61P25/28 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to steroid compounds (shown in the claims). The invention relates to a pharmaceutical composition for positive allosteric modulation of NDMA receptor activity, containing an effective amount of a compound or a pharmaceutically acceptable salt thereof according to the invention and a pharmaceutically acceptable carrier. The invention also relates to a method of treating a CNS disease mediated by positive allosteric modulation of NDMA receptor activity in a subject in need of such treatment, comprising administering an effective amount of a compound or a pharmaceutically acceptable salt thereof of the invention or a pharmaceutical composition based on the compound.

EFFECT: obtaining steroid compounds and their pharmaceutically acceptable salts that act as positive allosteric modulators (PAM) of NMDA and potentiate the function of the NMDA receptor.

37 cl, 2 tbl, 12 ex