QUINOXALINE-CONTAINING COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS Russian patent published in 2013 - IPC C07D498/18 C07D498/08 A61K31/4985 A61P31/14 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula I , where A is -(C=O); L₂₀₁ is absent; M is absent or is selected from O or NR₁; where R₁ is selected, during each appearance thereof, from hydrogen; L₁₀₁ is selected from -C₁-C₈ alkylene, -C₂-C₈ alkenylene or C₁-C₈ alkylene-O; or -C₁-C₈ alkylene, -C₂-C₈ alkenylene or C₁-C₈ alkylene-O, each of which is independently substituted with 1, 2 or 3 substitutes selected from C₁-C₈ alkyl or halogen, or two hydrogen atoms per carbon atom of -C₁-C₈ alkylene, -C₂-C₈ alkenylene or C₁-C₈ alkylene-O can be substituted with substitutes, where two substitutes, taken together, form a C₃-C₁₂ cycloalkyl ring; Z₁₀₁ is phenyl; phenyl substituted with 1, 2 or 3 halogens; or thienyl; W₁₀₁ is absent; X and Y, taken together with carbon atoms with which they are bonded, form a phenyl ring; R is -C₁-C₈ alkyl; R' is -C₁-C₈ alkyl, -C₂-C₈ alkenyl or CHQ₁Q₂; Q₁ and Q₂ each is independently F, Cl or Br; G is selected from -OH or -NHS(O)₂-R₂; R₂ is - C₃-C₁₂ cycloalkyl; m is 1; m' is 1; and s is 1. The invention also relates to a pharmaceutical composition which inhibits serine protease activity, particularly activity of hepatitis C virus (HCV) NS3-NS4A protease, based on said compounds.

EFFECT: obtaining novel compounds and a pharmaceutical composition based on said compounds, which can be used in medicine for treating hepatitis C.

19 cl, 4 dwg, 3 tbl, 1588 ex