ACTIVATOR OF KCNQ2-5 CHANNELS Russian patent published in 2020 - IPC C07C233/26 C07C233/29 C07C275/32 C07C275/40 C07D209/30 C07D213/40 C07D213/61 C07D213/74 C07D233/64 C07D239/26 C07D241/12 C07D271/06 C07D277/28 C07D307/52 C07D309/04 C07D333/20 C07D333/28 C07D413/06 A61K31/17 A61K31/341 A61K31/351 A61K31/381 A61K31/4045 A61K31/417 A61K31/422 A61K31/4245 A61K31/426 A61K31/435 A61K31/4545 A61K31/4965 A61K31/505 A61P13/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of general formula (I), or a pharmaceutically acceptable salt thereof. In formula (I) X¹ is CR⁶; X² is CR⁷; R¹¹ is (1) OR¹ or (2) NH₂; R¹ is (1) a hydrogen atom or (2) a C1-4 alkyl group; each R² and R³ independently represents (1) a hydrogen atom or (2) a C1-4 alkyl group which can be substituted with a halogen atom, where R² and R³ both can not simultaneously represent a hydrogen atom; each R⁴, R⁵, R⁶ and R⁷ independently represents (1) a hydrogen atom, (2) a halogen atom or (3) a C1-4 alkyl group, where R⁴ and R⁵ both can not simultaneously represent a hydrogen atom; Y is (1) -NH- or (2) a bond; R⁸ is (1) a hydrogen atom or (2) a C1-4 alkyl group; R⁹ represents (1) a cycle A, (2) C1-6 alkyl group, (3) -C1-4 alkylene-cycle A, (4) -cycle B-cycle C, (5) -cycle B-C1-4 alkylene -cycle C or (6) -cycle BO-cycle C, where alkyl group can be substituted with halogen atom. Cycle A is (1) C3-8 cycloalkane, (2) 3-8-member heterocycloalkane containing from one to three heteroatoms selected from oxygen and nitrogen atoms, (3) C3-12 monocyclic or bicyclic unsaturated carbocyclic ring or (4) 3–12-member monocyclic or bicyclic unsaturated heterocycle containing one to four heteroatoms selected from oxygen, nitrogen and sulfur atoms. Each cycle B and C independently represents (1) C3-8 cycloalkane, (2) 3–8-member heterocycloalkane, containing from one to three heteroatoms selected from oxygen and nitrogen atoms, (3) C3-7 monocyclic unsaturated carbocyclic ring or (4) 3–7-membered monocyclic unsaturated heterocycle containing one to three heteroatoms selected from oxygen, nitrogen and sulfur atoms. Each of cycles A, B and C can be independently substituted with one-five R¹⁰. Invention also relates to a method of preventing and/or treating a disease associated with KCNQ2-3 channel, use of the compound of formula (I) for preparing an agent for preventing and/or treating said disease and to a specific compound - 1-[(5-chloro-2-pyridinyl)methyl]-3-{2,6-dichloro-4-[(2S)-1,1,1-trifluoro-2-hydroxy-2-propanyl]phenyl}urea.

EFFECT: compounds can be used for preventing and/or treating a disease associated with KCNQ2-3 channel.

14 cl, 5 tbl, 79 ex