CARBOXYLIC ACID COMPOUND AND MEDICAL COMPOSITIONS CONTAINING THEREOF AS ACTIVE INGREDIENT Russian patent published in 2009 - IPC C07D265/36 C07D307/80 C07D319/20 C07D317/46 A61K31/538 A61K31/343 A61P37/08 A61P17/04 A61P17/10 A61P11/02 A61P13/10 A61P21/00 A61P25/20 A61P7/02 A61P25/06 A61P29/00 A61P11/00 A61P9/10 A61P37/06 A61P1/16 A61P19/02 A61P1/04 A61P1/14 

FIELD: medicine.

SUBSTANCE: carboxylic acid compounds are presented by formula (I) where R¹ represents (1) hydrogen atom, (2) C1-4alkyl; E represents -CO-; R² represents (1) halogen atom, (2) C1-6 alkyl, (3) trihalogen methyl; R³ represents (1) halogen atom, (2) C1-6alkyl; R⁴ represents (1) hydrogen atom; R⁵ represents (1) C1-6alkyl; represents phenyl; G represents (1) C1-6alkylene; represents 9-12-merous bicyclic heterocycle containing heteroatoms, chosen of 1-4 nitrogen atoms, one or two oxygen atoms; m represents 0 or an integer 1 to 4, n represents 0 or an integer 1 to 4, and i represents 0 or an integer 1 to 11 where R² can be identical or different provided m is equal to 2 or more, R³ can be identical or different provided n is equal to 2 or more, and R⁵ can be identical or different provided i is equal to 2 or more; both R¹² and R¹³, independently represent (1) C1-4alkyl, (2) halogen atom, (3) hydroxyl or (4) hydrogen atom, or R¹² and R¹³ together represent (1) oxo or (2) C2-5alkylene and where provided R¹² and R¹³ simultaneously represent hydrogen atom, carboxylic acid compound presented by formula (I), represents a compound chosen from the group including the compounds (1) - (32), listed in cl.1 of the patent claim. Besides the invention concerns a pharmaceutical composition based in the compound of formula I and to application of the compound of formula I for making the pharmaceutical composition.

EFFECT: there are produced new carboxylic acid derivatives with antagonistic activity with respect to DP receptor.

14 cl, 74 ex