SELF-SUSTAINING BIODEGRADABLE FILM BASED ON HYDROPHOBISATED HYALURONIC ACID, METHOD FOR PRODUCTION THEREOF AND USE THEREOF Russian patent published in 2020 - IPC C08B37/08 C08J3/02 C08J5/18 C08L5/08 A61K31/728 

FIELD: chemistry.

SUBSTANCE: present invention relates to a self-supporting film based on a hyaluronic acid ester and a method for production thereof. Said film comprises C₁₀-C₂₂-acylated hyaluronic acid derivative in accordance with general formula (I),

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in which R is H⁺ or Na⁺ and in which R₁ is H or -C(=O)C_xH_y, wherein x is an integer in range of 9 to 21, and y is an integer in range of 11 to 43, and C_xH_y is a linear or branched, saturated or unsaturated chain C₉-C₂₁, in which in at least one repeating link one or more R₁ are -C(=O)C_xH_y and in which n ranges from 12 to 4000. Film thickness makes 2–100 mcm. Method of producing film involves preparing solution containing C₁₀-C₂₂-acylated hyaluronic acid derivative in accordance with formula (I) in a mixture of water and C₁-C₆-alcohol, stirring solution and its application on substrate, drying in closed space and removal from substrate.

EFFECT: obtained film is insoluble in aqueous media, is formed only from acylated hyaluronan of general formula (I) without the need to add cross-linking substances and without additional treatment, contains a large amount of dry substance and can be used in medicine and veterinary science, in particular for producing anti-spike barriers.

18 cl, 10 dwg, 7 tbl, 37 ex