SELF-SUSTAINING BIODEGRADABLE FILM BASED ON HYDROPHOBISATED HYALURONIC ACID, METHOD FOR PRODUCTION THEREOF AND USE THEREOF Russian patent published in 2020 - IPC C08B37/08 C08J3/02 C08J5/18 C08L5/08 A61K31/728 

Abstract RU 2712174 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to a self-supporting film based on a hyaluronic acid ester and a method for production thereof. Said film comprises C10-C22-acylated hyaluronic acid derivative in accordance with general formula (I),

,

in which R is H+ or Na+ and in which R1 is H or -C(=O)CxHy, wherein x is an integer in range of 9 to 21, and y is an integer in range of 11 to 43, and CxHy is a linear or branched, saturated or unsaturated chain C9-C21, in which in at least one repeating link one or more R1 are -C(=O)CxHy and in which n ranges from 12 to 4000. Film thickness makes 2–100 mcm. Method of producing film involves preparing solution containing C10-C22-acylated hyaluronic acid derivative in accordance with formula (I) in a mixture of water and C1-C6-alcohol, stirring solution and its application on substrate, drying in closed space and removal from substrate.

EFFECT: obtained film is insoluble in aqueous media, is formed only from acylated hyaluronan of general formula (I) without the need to add cross-linking substances and without additional treatment, contains a large amount of dry substance and can be used in medicine and veterinary science, in particular for producing anti-spike barriers.

18 cl, 10 dwg, 7 tbl, 37 ex

Similar patents RU2712174C2

Title Year Author Number
C6-C18-ACYLATED DERIVATIVE OF HYALURONIC ACID, METHOD FOR PRODUCTION NANOMICELLAR COMPOSITION BASED THEREON, METHOD FOR PRODUCTION AND METHOD FOR PRODUCTION OF STABILIZED NANOMICELLAR COMPOSITION AND ITS APPLICATION 2013
  • Smezhkalova Daniela
  • Khuerta-Angeles Gloriya
  • Bobek Martin
  • Khermannova Martina
  • Vistezhnova Lyusi
  • Novotnyj Yaroslav
  • Prikopova Eva
  • Nesporova Kristina
  • Nemkova Miroslava
  • Slezingerova Klara
  • Kulkhanek Yaromir
  • Kozikova Dagmar
  • Sogorkova Yana
  • Kutsera Yan
  • Klejn Pavel
  • Velebnij Vladimir
RU2640287C2
ANTI-TUMOUR COMPOSITION BASED ON HYALURONIC ACID AND INORGANIC NANOPARTICLES, METHOD FOR PRODUCTION THEREOF AND USE THEREOF 2015
  • Smejkalova Daniela
  • Nesporova Kristina
  • Tepla Martina
  • Syrovatka Jakub
  • Huerta-Angeles Gloria
  • Pospisilova Martina
  • Matuska Vit
  • Mrazek Jiri
  • Galisova Andrea
  • Jirak Daniel
  • Velebny Vladimir
RU2686679C2
HYALURONIC ACID DERIVATIVES CAPABLE OF FORMING HYDROGELS, SYNTHESIS METHOD THEREOF, HYDROGELS BASED ON SAID DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF 2013
  • Volfova Lutsie
  • Pravda Martin
  • Foglarova Martsela
  • Nemtsova Miroslava
  • Niedova Krzhishtof
  • Velebni Vladimir
RU2586931C2
MIXED ESTERS OF BUTYRIC ACID AND FORMIC ACID AND ACIDIC POLYSACCHARIDES AND PRODUCTION AND USE THEREOF AS SKIN COSMETICS 2008
  • Bosko Marko
  • Stuchchi Luka
  • Dzhanni Rita
  • Trevizan Antonija
RU2490280C2
LOW-MOLECULAR POLYSULPHATED HYALURONIC ACID DERIVATIVE AND MEDICINAL AGENT CONTAINING SAME 2010
  • Kakekhi Kadzuaki
  • Asai Khiroaki
  • Khajasi Naokhiro
  • Simidzu Satosi
  • Goto Fumitaka
  • Koga Jasuo
  • Tomojasu Takakhiro
  • Taki Takao
  • Kato Jusuke
  • Nakadzato Satoru
  • Takaba Dzundzi
  • Adzuma Atsusi
  • Khirano Vakako
  • Idzumi Kadzunari
  • Kasimoto Minoru
  • Sakamoto Joko
  • Khajasi Takasi
  • Nisida Masaru
RU2519781C2
POLYSACCHARIDE WITH GRAFTED ANTIOXIDANT AND METHOD OF PREPARING THEREOF 1996
  • Ngujen Tuen Tankh
RU2174985C2
STABILIZED HYALURONIC ACID 2019
  • Sachsenhofer, Robert
RU2805502C2
MEDICAL DEVICES COVERED WITH QUICKLY-DISSOLVABLE BIOCOMPATIBLE COATING 2006
  • Dornis Mikhel'
  • Larsen Kristian Klejn
  • Andersen Terese
RU2403069C2
HYDROGEL WATER-SOLUBLE COMPOSITION BASED ON HYALURONIC ACID AND POLYVALENT METAL IONS AND A METHOD FOR PRODUCTION THEREOF 2019
  • Ivanov Pavel Leonidovich
  • Khabarov Vladimir Nikolaevich
RU2710074C1
FUNCTIONALIZED HYALURONIC ACID OR ITS DERIVATIVE FOR THE TREATMENT OF INFLAMMATORY CONDITIONS 2018
  • Byankini, Dzhulio
  • Kallegaro, Lanfranko
RU2792001C2

RU 2 712 174 C2

Authors

Foglarova, Marcela

Huerta-Angeles, Gloria

Nesporova, Kristina

Slesingrova, Klara

Minarik, Antonim

Chmelar, Josef

Sulakova, Romana

Karel, Sergej

Velebny, Vladimir

Dates

2020-01-24Published

2016-03-09Filed