PYRAZOLO[1,5-A]TRIAZIN-4-AMINE DERIVATIVES APPLICABLE IN THERAPY Russian patent published in 2020 - IPC C07D487/04 A61K31/53 A61P31/12 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. In formula (I), W is CH₂; X is C; cycle A is phenyl or 5- or 6-member heteroaryl, wherein said heteroaryl contains 1, 2, 3 or 4 heteroatoms selected from N, O and S; m is integer from 0 to 2; each R¹ is selected independently from (C1-C6) alkyl, optionally substituted with one or more halogen atoms, R²O, halogen, R⁵C(O)N(R⁶), R⁹S(O)₂, R¹⁰S(O)₂N(H), ^-O and R¹⁴R¹⁵NS(O)₂; and when m is at least 2, two R¹, attached to adjacent atoms of cycle A, can form, together with atoms to which they are attached, 5- or 6-member heterocycle or carbocycle; wherein heterocycle contains 1 or 2 heteroatoms selected from oxygen; each R², R⁵, R⁶, R⁹, R¹⁰ and R¹⁴ is selected independently from H and (C1-C6) alkyl, wherein any alkyl is optionally substituted with one or more halogen atoms; R¹⁵ is selected from H, (C1-C6) alkyl, R¹⁶C (O) and R¹⁷OC(O); and each R¹⁶ and R¹⁷ is selected independently from H and (C1-C6) alkyl, where any alkyl is optionally substituted with one or more halogen atoms. Invention also relates to a pharmaceutical composition, to use of the compound, to a method of treating enteroviral infection.

EFFECT: technical result: obtaining novel compounds of formula (I), having the properties of a phosphatidyl inositol-4-kinase IIIβ inhibitor.

17 cl, 5 tbl, 32 ex