PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL COMPOUNDS Russian patent published in 2019 - IPC C07D487/04 A61K31/519 A61P31/14 A61P31/12 

FIELD: chemistry.

SUBSTANCE: invention relates to a novel compound of formula (Ie) having antiviral RNA activity, in particular picornavirus activity, for example, paraechovirus, cardiovirus, enterovirus, such as EV virus, Coxsackie, polyellitis, rhinovirus, and hepatitis virus. In formula (Ie) (Ie) R¹ is methyl; each R² is methoxy; R³ is methyl; m is integer from 0 to 2; each R⁴ is independently selected from C1-C6 alkyl, R¹²O, halogen atom, R¹³R¹⁴NC(O) -, R¹⁶C(O)N(R¹⁵)-, R¹⁷OC(O)-, R¹⁹S(O)₂-, R²⁰S (O)₂N(H) -, NH₂S (O)₂-, R²¹C (O) -, N (R²²) (R²³) - and ^-O-; R¹², R¹³, R¹⁴, R¹⁵, R²² and R²³ are independently selected from H and C1-C6 alkyl; R¹⁶, R¹⁷, R¹⁹, R²⁰ and R²¹ are independently selected from C1-6 alkyl; any alkyl is optionally substituted with one or more F atoms; or two R⁴, attached to adjacent atoms of cycle B, form together with atoms to which they are bonded, 5- or 6-member heterocyclic or carbocyclic ring or a benzene ring; cycle B is 5- or 6-member heteroaryl containing 1 or 2 heteroatoms selected from N, O and S; or cycle B is phenyl.

EFFECT: compound can be used for treating a viral infection, for example caused by a non-enveloped virus with single-stranded (+) RNA.

20 cl, 1 dwg, 6 tbl, 112 ex