FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to ethynyl derivatives of formula I, where R1 is a hydrogen atom or F; n equals 1 or 2. Invention also relates to a pharmaceutical composition having negative allosteric modulator mGluR5 activity, based on said compounds.
I.
EFFECT: technical result is obtaining novel compounds and a pharmaceutical composition based thereon, which can be used in medicine for treating anxiety and pain, depression, Parkinson's disease and gastroesophageal reflux disease (GERD).
9 cl, 2 dwg, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| POSITIVE ALLOSTERIC MODULATORS (PAM) | 2010 |
|
RU2561920C2 |
| ARYLETHINYL DERIVATIVES | 2011 |
|
RU2573560C2 |
| ETHYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR | 2016 |
|
RU2721776C2 |
| ETHINYL DERIVATIVES | 2010 |
|
RU2553461C2 |
| ACETYLENE DERIVATIVES, METHOD OF THEIR OBTANING, PHARMACEUTICAL COMPOSITION BASED ON THEM AND THEIR USE AS ANTAGONISTS OF METABOTHROPIC GLUTAMATE RECEPTORS (MGLUR5) | 2002 |
|
RU2341515C2 |
| IMIDAZOLE DERIVATIVES AS mGluR5 ANTAGONISTS | 2010 |
|
RU2527106C2 |
| 6-(PYRIMIDINOAMINO-PYRIDINE)BENZOIMIDAZOLE DERIVATIVES, USEFUL FOR TREATMENT OF CANCER | 2014 |
|
RU2670762C2 |
| AZETIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | 2012 |
|
RU2615995C2 |
| COMBINATIONS CONTAINING mGluR MODULATORS FOR TREATING PARKINSON'S DISEASE | 2009 |
|
RU2496494C2 |
| AROYLAMINO- AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | 2010 |
|
RU2517701C2 |
