FIELD: chemistry.
SUBSTANCE: present invention relates to production of multi-specific structures. Invention discloses polynucleotides, an expression vector, a host cell and a method of producing a multispecific or bispecific antibody. Produced antibody consists of three polypeptide chains: (Vxx)nVx-Cx-X-V1; (Vyy)nVy-Cy and V2, where Vx, Vxx, V1, V2, Vy and Vyy denote variable domains, Cx and Cy are constant regions, X is a linker, n independently denotes 0 or 1.
EFFECT: present invention can be used in preparing therapeutic preparations.
28 cl, 7 dwg, 5 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| STRUCTURE OF POLYPEPTIC ANTIBODIES | 2015 |
|
RU2725812C2 |
| POLY-SPECIFIC ANTIBODY STRUCTURES | 2015 |
|
RU2784673C2 |
| MULTISPECIFIC ANTIBODY CONSTRUCTS | 2015 |
|
RU2710730C2 |
| MOLECULES WITH CD45 AND CD79 SPECIFICITY | 2015 |
|
RU2747980C2 |
| POLYSPECIFIC ANTIBODIES CONTAINING ANTIBODY OF FULL LENGTH AND ONE-CHAIN FRAGMENTS FAB | 2010 |
|
RU2598248C2 |
| TRI- OR TETRASPECIFIC ANTIBODIES | 2010 |
|
RU2570633C2 |
| POLYPEPTIDES FOR BONDING WITH "RECEPTOR OF ADVANCED GLYCATION ENDPRODUCTS", THEIR COMPOSITIONS AND METHODS, WHICH THEY TAKE PART IN | 2010 |
|
RU2558301C2 |
| MOLECULES WITH SPECIFICITY WITH RESPECT TO CD79 AND CD22 | 2015 |
|
RU2743590C2 |
| BINDING MOLECULES INDUCING CELLULAR ACTIVATION | 2019 |
|
RU2770620C1 |
| IMPROVED EXPRESSION VECTORS OF MAMMALS AND THEIR USE | 2009 |
|
RU2502800C2 |
