FIELD: medicine.
SUBSTANCE: present invention provides a method of determining the effectiveness of compositions used for treating articular cartilage diseases in mammals. Method involves determining the change in levels of the biomarker of the c-terminal cross-linked telopeptide of type II collagen (CTX-II) in a mammal before physical exercise and after physical exercise, then administering to a mammal a composition used for treating articular cartilage diseases, and determining the change of levels of said biomarker in a mammal before physical exercise and after physical exercise.
EFFECT: proposed is a method for evaluating medicines for articular cartilages.
18 cl, 2 dwg, 10 tbl, 7 ex
