FIELD: medicine.
SUBSTANCE: present invention provides a method of determining the effectiveness of compositions used for treating articular cartilage diseases in mammals. Method involves determining the change in levels of the biomarker of the c-terminal cross-linked telopeptide of type II collagen (CTX-II) in a mammal before physical exercise and after physical exercise, then administering to a mammal a composition used for treating articular cartilage diseases, and determining the change of levels of said biomarker in a mammal before physical exercise and after physical exercise.
EFFECT: proposed is a method for evaluating medicines for articular cartilages.
18 cl, 2 dwg, 10 tbl, 7 ex
| Title |
Year |
Author |
Number |
| METHODS OF TREATING THE DEREGULATED NUCLEAR FACTOR OF SHORT-CHAIN KAPPA ACTIVATED CELL ENHANCER IN (NF-κB) IN ORGANISM IN NEED THEREOF USING EGGSHELL MEMBRANE COMPOSITIONS |
2015 |
|
RU2713656C2 |
| METHODS AND COMPOSITIONS FOR DIAGNOSTICS OF ANKYLOSING SPONDYLITIS WITH APPLICATION OF BIO-MARKERS |
2006 |
- Maksimovich Uolter P.
- Vong Robert L.
|
RU2438704C2 |
| [(S)-1-CARBAMOYL-2-(PHENYLPYRIMIDIN-2-YLAMINO)ETHYL]AMIDE 2-(2-METHYLAMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID FOR USE IN TREATING OSTEOARTHRITIS-RELATED PAIN |
2015 |
- Paehler, Tobias
- Flechsenhar, Klaus
- Grothe, Kirsten
- Lunnon, Martin
- Jan, Christelle
|
RU2687094C2 |
| COMBINATION OF A CHONDROPROTECTIVE AGENT WITH AN NSAID |
2017 |
- Chekalov Aleksej Valerevich
|
RU2742172C2 |
| METHOD FOR DETECTING EARLY CHANGES IN CARTILAGE TISSUE AT PRE X-RAY STAGES OF KNEE OSTEOARTHRITIS |
2020 |
- Gladkova Ekaterina Vyacheslavovna
- Romakina Nataliya Aleksandrovna
- Titova Yuliya Ivanovna
- Ulyanov Vladimir Yurevich
|
RU2750126C1 |
| PHARMACEUTICAL COMPOSITIONS SUITABLE FOR DELIVERY TO JOINT AND THEIR USE IN TREATMENT OF JOINT PAIN |
2019 |
- Tsen, Yun-Lun
- Shikh, Sheue-Fan
- Chan, Po-Chun
- Chan, Lu
|
RU2810788C2 |
| METHODS OF DIAGNOSING AND TREATING RHEUMATOID ARTHRITIS |
2020 |
- Zilbershtejn, Moshe E.
- Bojapati, Anita
- Msikhid, Zherom
|
RU2828027C2 |
| METHODS AND COMPOSITIONS FOR DIAGNOSTICS OF OSTEOARTHRITIS AT CAT FAMILY |
2008 |
- Al'-Murrani Samer Valid Kkhedkhejer
- Shenkherr Uill'Jam Dehvid
|
RU2504586C2 |
| COMBINED TREATMENT OF ARTHRITIS |
2020 |
- Jonassen, Tomas, Engelbrekht, Nordkild
|
RU2828044C2 |
| METHOD OF TREATING PATIENTS WITH RHEUMATOID ARTHRITIS |
2013 |
- Burduli Nikolaj Mikhajlovich
- Kulova Laura Aleksandrovna
- Burduli Nina Nikolaevna
|
RU2554232C1 |
