FIELD: chemistry.
SUBSTANCE: invention relates to use of [(S)-1-carbamoyl-2-(phenylpyrimidin-2-ylamino)ethyl]amide 2-(2-methylaminopyrimidin-4-yl)-1H-indole-5-carboxylic acid for treating pain associated with osteoarthritis in the knee joint, including in the patients with effusion and synovitis. Said compound is used as an active component for a pharmaceutical composition presented in the form of a single dose for intra-articular introduction. Dose for intraarticular administration ranges from 15 to 60 mg, preferably 60 mg. Invention also relates to a pharmaceutical composition for treating pain associated with osteoarthritis in the knee joint, including in patients with effusion and synovitis.
EFFECT: composition contains an effective amount of [(S)-1-carbamoyl-2-(phenylpyrimidin-2-ylamino)ethyl]amide 2-(2-methylaminopyrimidin-4-yl)-1H-indole-5-carboxylic acid as an active ingredient and pharmaceutically acceptable adjuvants.
13 cl, 2 dwg, 3 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CRYSTALLINE FORMS OF [(S)-1-CARBAMOYL-2-(PHENYLPYRIMIDIN-2-YLAMINO)ETHYL]AMIDE 2-(2-METHYLAMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBONIC ACID | 2012 |
|
RU2631320C2 |
| METHOD OF TREATING KNEE OSTEOARTHRITIS | 2024 |
|
RU2822321C1 |
| PHARMACEUTICAL COMPOSITIONS SUITABLE FOR DELIVERY TO JOINT AND THEIR USE IN TREATMENT OF JOINT PAIN | 2019 |
|
RU2810788C2 |
| COMBINATION FOR TREATING OSTEOARTHRITIS | 2010 |
|
RU2560844C2 |
| PHARMACEUTICAL COMPOSITION FOR TREATMENT OF OSTEOARTHRITIS, CONTAINING CLODRONIC ACID AND HYALURONIC ACID | 2006 |
|
RU2414908C2 |
| OSTEOARTHRITIS TREATMENT | 2009 |
|
RU2712273C2 |
| METHOD FOR TREATING CHRONIC GONARTHRITIS IN PATIENTS WITH OSTEOARTHROSIS | 2005 |
|
RU2293560C2 |
| METHOD FOR TREATING OSTEOARTHRITIS OF KNEE JOINT | 2019 |
|
RU2717345C1 |
| METHOD OF TREATING PATIENTS WITH OSTEOARTHRITIS | 2009 |
|
RU2421190C2 |
| PHARMACEUTICAL COMPOSITION FOR SAFE AND EFFECTIVE TREATMENT OF KNEE AND/OR HIP JOINT PAIN | 2019 |
|
RU2786232C2 |
