METHOD FOR DETECTING EARLY CHANGES IN CARTILAGE TISSUE AT PRE X-RAY STAGES OF KNEE OSTEOARTHRITIS Russian patent published in 2021 - IPC G01N33/48 

FIELD: medicine, orthopedy in particular.

SUBSTANCE: invention relates to medicine, namely to traumatology and orthopedics, rheumatology, and deals with a method for detecting early changes in cartilage tissue at the pre X-ray stages of osteoarthritis of the knee joint. The essence of the method: the concentration of COMP in the blood serum and the content of the level of CTX-II in the urine are once determined with the calculation of the individual coefficients of С_COMP and С_CTX-II as a quotient of dividing the absolute value of the concentration of the latter in the examined, С_COMPres and С_CTX-IIres by the median value of the same indicators evaluated in a group of healthy individuals С_COMPnorm and С_CTX-IInorm. Additionally, magnetic resonance imaging is performed in the T2-relaxometry mode with the determination of the C_RELAX coefficient equal to the ratio of the average T2-relaxation time measured in the loaded areas of t_stress to the average T2-relaxation time in the intact areas of the articular hyaline cartilage t_intact in the projection of the medial condyles of the tibia in the subject. Then the total diagnostic coefficient C, equal to the sum of the coefficients of C_COMP, C_STX-II and C_RELAX is calculated. With C<4.27, the absence of osteoarthritis is diagnosed, with C ≥4.27, its presence.

EFFECT: use of this invention will make it possible to identify early changes in the cartilage tissue at the pre X-ray stages of knee osteoarthritis due to a quantitative aggregate assessment of its local and systemic manifestations that objectively characterize the processes of remodeling articular hyaline cartilage.

1 cl, 3 ex