TYLOSIN DERIVATIVES AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2020 - IPC C07H17/08 A61K31/7048 A61P31/04 

FIELD: veterinary science; pharmaceutics.

SUBSTANCE: invention relates to new tylosin derivatives, pharmaceutical and veterinary compositions based thereon, applicable in methods of treating bacterial infections. Said derivative is a compound of formula (IIa)

,

or a pharmaceutically acceptable salt thereof; where R⁵ is a hydroxy, one of R¹¹ and R¹² is hydrogen or C1-C6-alkyl optionally substituted with a substituent selected from phenyl or halogen-substituted phenyl; and other of R¹¹ and R¹² is C1-C3-alkyl substituted with 1,2,3-triazol, substituted in position 4 with one substitute selected from pirinyl, thiophenyl, quinolinyl or isoquinolinyl.

EFFECT: novel effective antibacterial derivatives applicable for treating and preventing bacterial infections in an animal and for preparing compositions thereof, which can be used in methods of treating and preventing bacterial infections in an animal.

12 cl, 9 tbl