FIELD: chemistry.
SUBSTANCE: invention relates to uridine diphosphate-3-O-(hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) enzyme inhibitors of formula (I) 
where A is 3,5-disubstituted nucleus of 1,2,4-oxadiazole (in the form of two regioisomers 1 and 2) or 2,5-disubstituted nucleus of 1,3,4-oxadiazole 3: 
B is a functional group of hydroxamic acid (C(O)NHOH), free or conjugated with an aliphatic or aromatic linker: 
R1 is H, F, H3CO, H3C; R2 is H, F, C1, I, H3CO, H3C; R3 is H, F, C1, I, H3CO, F3CO; R4 is H, F; R5 is H, F.
EFFECT: synthesis of new chemical compounds, which are inhibitors of the LpxC enzyme, having pharmacological activity, a decrease in the cytotoxicity of the synthesized chemical compounds, which are inhibitors of the LpxC enzyme, improvement of ADME-properties of synthesized chemical compounds, which are inhibitors of LpxC enzyme, is shown.
35 cl, 11 tbl, 99 ex, 13 dwg
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