FIELD: medicine; pharmaceuticals.
SUBSTANCE: group of inventions relates to pharmacy and oncology. Disclosed are a combination of a first compound selected from N-(3,5-dimethoxyphenyl)-N'-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine or its salt, solvate and N-(2-fluoro-3,5-dimethoxyphenyl)-N-(1H-imidazol-2-ylmethyl)-3-(1-methyl-1H-pyrazole-4-yl)pyrido[2,3-b]pyrazine-6-amine or salt thereof, solvate (both - FGFR inhibitors) and a second compound, a cMet inhibitor for preventing or treating cancer, a pharmaceutical composition of the same purpose, comprising said combination, using said combination (pharmaceutical composition - embodiments) for producing a drug for treating cancer and corresponding methods of preventing or treating cancer (embodiments).
EFFECT: technical result: in cancer cells resistant to declared inhibitors of FGFR, increased regulation of oncogene Met, therefore combination of inhibitor cMet with declared inhibitors of FGFR effectively overcomes this resistance in cancer treatment.
23 cl, 4 dwg, 2 tbl
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