FIELD: medicine; pharmaceutics.
SUBSTANCE: group of inventions relates to medicine and pharmaceutics and can be used to treat cancer with resistance to immune checkpoint inhibitors. Disclosed is use of (S)-1-(3-(4-amino-3-((3,5-dimethoxyphenyl)ethynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl)prop-2-en-1-one or a salt thereof in a combination therapy with pembrolizumab, as well as a method of treating cancer with resistance to immune checkpoint inhibitors, involving administering said combination.
EFFECT: group of inventions provides treating cancer with resistance to immune checkpoint inhibitors by increasing T-cells and enhancing the effect of pembrolizumab by reducing the number of myeloid suppressor cells (MDSC).
6 cl, 1 dwg, 2 ex
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Year |
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Number |
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