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(19)

(11)

2 718 044

(13)

(51)

IPC

A61K9/20(2006-01-01)

A61K31/47(2006-01-01)

A61K31/443(2006-01-01)

A61P43/00(2006-01-01)

(21) (22)

Application

2019107168, 2014-10-31

(24)

Start date

2014-10-31

(22)

Actual filing date

2014-10-31

(45)

Published

2020-03-30

(72)

Inventor

Swinney, Kelly, AnnHurter, Patricia, NellNadig, David, E.Smith, DavidThomas, Vance, HaydenWarman, Martin, Paul

(73)

Holder

Vertex Pharmaceuticals Incorporated

METHOD OF PRODUCING PHARMACEUTICAL COMPOSITIONS FOR TREATING CFTR MEDIATED DISEASES Russian patent published in 2020 - IPC A61K9/20 A61K31/47 A61K31/443 A61P43/00

Abstract RU 2718044 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: described are methods for preparing pharmaceutical compositions containing 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (compound 1) in form I and a solid dispersion containing substantially amorphous N-(5-hydroxy-2,4-di-tert-butylphenyl)-4-oxo-1H-quinoline-3-carboxamide (compound 2), related methods of treating, reducing severity or symptomatic treatment of CFTR mediated diseases, such as cystic fibrosis, methods for their introduction and kits with them.

EFFECT: disclosed is a method for preparing pharmaceutical compositions for treating CFTR mediated diseases.

21 cl, 34 tbl, 25 dwg

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RU 2 718 044 C2

Authors

Swinney, Kelly, Ann

Hurter, Patricia, Nell

Nadig, David, E.

Smith, David

Thomas, Vance, Hayden

Warman, Martin, Paul

Dates

2020-03-30—Published

2014-10-31—Filed