FIELD: biotechnology.
SUBSTANCE: invention refers to biotechnology, particularly to production of nybomycin antibiotic. Streptomyces iakyrus RNCIM As-2084 strain is cultured. Strain is grown on a nutrient medium containing glucose, asparagine and potassium hydrogenorthophosphate and water at specified content of components. Culture liquid is successively filtered through paper membranes and then membrane filters. Filtered culture liquid is fractionated on a selective sorbent with subsequent desorption with 20±3 % aqueous solution of acetonitrile at neutral pH and incubation of the eluate until crystals of nybomycin are deposited.
EFFECT: invention increases output of nybomycin.
4 cl, 4 dwg, 1 tbl, 1 ex
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