COMPOSITIONS OF IMMUNOGENIC/THERAPEUTIC GLYCOCONJUGATES AND USE THEREOF Russian patent published in 2020 - IPC A61K39/385 A61K39/39 A61P35/00 

FIELD: medicine; oncology.

SUBSTANCE: group of inventions is intended for immunotherapy of malignant tumors. Pharmaceutical composition is a vaccine inducing formation of anti-tumor antibodies. Vaccine contains immunogenic glycoconjugate Globo-H-KLH (OBI-822), in which molecules of tumor antigen Globo-H are covalently linked to molecules of structural subunits of hemocyanin KLH by one or more residues of amino acids. Said composition has an epitope ratio of Globo-H molecule / molecule of structural subunit KLH in range from 750 to 3000. In one embodiment, the Globo-H molecule is bound to KLH by covalent bonding with 4-(4-N-maleimidomethyl)cyclohexane-1-carboxylhydrazide (MMCCH). In another version, said composition may contain an adjuvant α-galactosylceramide(α-GalCer). In one embodiment, the method of treating a malignant tumor involves administering to a patient a therapeutically effective amount of said pharmaceutical composition. In another version, said composition is administered to an individual in order to obtain monoclonal antibodies for therapeutic or diagnostic use.

EFFECT: group of inventions enables to elicit a high level of the immune response directed to Globo-H.

46 cl, 7 tbl, 38 dwg, 9 ex