MESSENGER RNA VACCINES AGAINST WIDE RANGE OF CORONAVIRUS VARIANTS Russian patent published in 2024 - IPC A61K39/215 C07K14/05 C12N15/86

Abstract RU 2826172 C2

FIELD: biotechnology.

SUBSTANCE: described is a modified nucleic acid molecule coding a modified spike protein, obtained from the spike protein SARS-CoV-2, having a deletion of glycosylation sites in the receptor-binding domain (RBD), subunit 1 (S1) domain or subunit 2 (S2) domain. Also described is a method for preventing or treating coronavirus infection, comprising administering a composition with an effective amount of a modified nucleic acid molecule to a subject infected with or at risk of being infected with a coronavirus.

EFFECT: vaccine induces a broad protective immune response against coronavirus and its variants.

19 cl, 29 dwg, 2 tbl, 1 ex

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RU 2 826 172 C2

Authors

Wong, Chi-Huey

Wu, Chung-Yi

Ma, Che

Fan, Chen-Yu

Dates

2024-09-05—Published

2022-04-12—Filed