NEW PHARMACEUTICAL COMPOSITION CONTAINING NONIONIC SURFACTANTS Russian patent published in 2020 - IPC A61K9/10 A61K9/14 A61K9/48 A61K31/00 A61K47/14 A61K47/22 A61K47/26 

FIELD: medicine.

SUBSTANCE: group of inventions refers to a pharmaceutical composition for treating or preventing a malignant growth, wherein the malignant neoplasm is non-small cell lung cancer containing a) 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-3-carbonitrile or a pharmaceutically acceptable salt thereof, b) a non-ionic surfactant A, at room temperature in a solid state, wherein the surfactant A is a tocopherol derivative or a lauroyl polyoxyl glyceride, and c) a non-ionic surfactant B, at room temperature in a liquid state, where surfactant B is a polyoxyethylene sorbitol fatty acid ester or propylene glycol monolaurate, where the hydrophilic-lipophilic balance (HLB) value of the surfactants A and B is independently equal to or greater than 8 and where the active substances or their pharmaceutically acceptable salts are dispersed in the matrix, formed by said non-ionic surfactants A and B, as well as to capsule containing pharmaceutical composition, to use of a pharmaceutical composition for preparing a drug for treating or preventing a malignant growth, wherein the malignant growth is non-small-cell lung cancer, and the use of a pharmaceutical composition for treating or preventing a malignant growth, wherein the malignant neoplasm is non-small-cell lung cancer.

EFFECT: group of inventions provides higher bioavailability 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

37 cl, 3 dwg, 21 tbl, 12 ex