METHOD OF PRODUCING A NOVEL NITROGEN-CONTAINING COMPOUND OR A SALT THEREOF AND PRODUCING AN INTERMEDIATE THEREOF Russian patent published in 2020 - IPC C07D471/04 C07D255/02 C07D257/02 C07F1/08 C07F5/00 A61K31/4375 A61K31/555 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a method of producing a compound of formula [11], or a salt thereof, comprising: (1) a step for reacting a compound of formula [1] or a salt thereof:

where R¹ represents a hydrogen atom or an amino protecting group which is selected from C_1-6 alkoxycarbonyl group, a chromansulphonyl group substituted with C_1-6 alkyl groups, or dihydrobenzofuransulphonyl group substituted with C_1-6 alkyl groups; R² represents C_1-6 alkyl group; L¹ is a group of formula [18a]

where R^5a and R^6a are a hydrogen atom and r¹ is integer from 1 to 6; and L² is a group of formula [18b]

where R^5b and R^6b are a hydrogen atom and r² is integer from 1 to 6; with a compound of formula [3], or a salt thereof in the presence of a condensing agent

where L³ is a group of formula [18c]

where R^5c and R^6c represent a hydrogen atom and r³ is integer from 1 up to 6; A¹ is any of groups of formulas [4] or [5]:

where * is a binding position; R⁷ are identical and represent C_1-6 alkyl group; and m is integer from 1 to 3; to obtain a compound of formula [10], or a salt thereof:

and (2) a step for deprotection of a compound of formula [10], or a salt thereof in the presence of an acid, to obtain compound [11], in which A² is any of groups of formulas [12] or [13]:

Invention also relates to a method of producing a metal complex, to a compound of formula [19], to a compound of formula [3], to a compound of formula [11], to a compound of formula [38], to complexes of compounds, structural formulas of compounds are given in the claim.

EFFECT: disclosed is a method of producing novel nitrogen-containing compounds of formula [11], which can be used for treating diseases associated with integrin.

17 cl, 6 dwg, 7 tbl, 27 ex