THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5HT RECEPTOR LIGANDS AND USE THEREOF Russian patent published in 2011 - IPC C07D498/02 C07D495/04 C07D495/06 A61K31/55 A61P25/06 A61P25/08 A61P25/18 A61P25/20 A61P25/22 A61P25/24 A61P3/04 A61P3/10 A61P43/00

Abstract RU 2434872 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula , where X denotes S; R₁ and R₂ taken together with atoms to which they are bonded form a 5-member carbocycle, substituted with up to two substitutes selected from alkyl and CF₃; R₃ is selected from a group consisting of a hydrogen atom and C_1-8-alkyl; R_3a denotes a hydrogen atom; R₄ denotes a hydrogen atom; R_4a denotes a hydrogen atom; R₅ denotes a hydrogen atom; R_5a denotes a hydrogen atom; R₆ denotes a hydrogen atom; R_6a denotes a hydrogen atom; R₇ denotes a hydrogen atom; or pharmaceutically acceptable salts thereof. The invention also relates to compounds of the given formula, compounds selected from the group, as well as a pharmaceutical composition.

EFFECT: obtaining novel biologically active compounds which modulate serotonin receptor activity.

6 cl, 19 ex, 1 tbl

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RU 2 434 872 C2

Authors

T'Jumi L. Natan

Bom Dehvid K.

Bennani Jussef L.

Robardzh Majkl Dzh.

Dates

2011-11-27—Published

2007-01-17—Filed