NEUTRALIZING BINDING MOLECULES DIRECTED AGAINST INFLUENZA VIRUS, AND METHODS OF THEIR APPLICATION Russian patent published in 2020 - IPC C07K16/08 A61K39/00 A61K31/00 C07K16/10 

FIELD: biochemistry.

SUBSTANCE: described is a group of inventions comprising an isolated binding molecule which specifically binds to influenza A virus and influenza virus B, recovered polynucleotide, coding said binding molecule, a vector coding said binding molecule, a host cell capable of expressing said molecule, composition for preventing or treating an influenza A infection, influenza B infection or a combination thereof in a patient, a method of producing said binding molecule, a method of preventing or treating influenza A infection, influenza B infections or a combination thereof in a patient. In one embodiment, the recovered binding molecule comprises a Fv domain of a first antibody which is capable of binding to influenza A virus haemagglutinin (HA) and neutralize at least one subtype of group 1 and at least one subtype of group 2 of influenza A virus and domain Fv of second antibody, which is able to bind to HA influenza B virus and neutralize influenza virus B of two phylogenetically different lines.

EFFECT: invention extends the range of products associated with influenza A and influenza B viruses.

12 cl, 6 dwg, 12 tbl, 9 ex