Patenton — panteon of patents

(19)

RU

(11)

2 649 368

(13)

C2

(51)

IPC

C07K16/18(2006-01-01)

C07K14/54(2006-01-01)

A61K51/10(2006-01-01)

C12N1/20(2006-01-01)

C12N15/63(2006-01-01)

A61P19/00(2006-01-01)

(21) (22)

Application

2013115891, 2013-04-09

(24)

Start date

2008-10-27

(22)

Actual filing date

2013-04-09

(45)

Published

2018-04-02

(72)

Inventor

Kaspar ManuelaShvager KatrinTrachsel Evelin

(73)

Holder

Filodzhen S.P.A.

ANTIGEN ASSOCIATED WITH RHEUMATOID ARTHRITIS Russian patent published in 2018 - IPC C07K16/18 C07K14/54 A61K51/10 C12N1/20 C12N15/63 A61P19/00 

Abstract RU 2649368 C2

FIELD: biotechnology; medicine; pharmaceutics.

SUBSTANCE: present invention relates to biotechnology and pharmaceutics, namely to antibody conjugates for treating rheumatoid arthritis in a patient. Antibody included in these conjugates specifically binds Extra-Domain-A (ED-A) to fibronectin and is conjugated to interleukin-10. Present invention also discloses a nucleic acid encoding said conjugate, a host cell for its production, a pharmaceutical composition for treating rheumatoid arthritis in a patient, as well as a method of producing said conjugate and a method for treating rheumatoid arthritis, a method for delivering interleukin-10 to regions of rheumatoid arthritis and method diagnosis of rheumatoid arthritis in a patient with its use.

EFFECT: present invention provides successful treatment of rheumatoid arthritis by selective delivery of interleukin-10 to sites of disease localization.

35 cl, 8 dwg, 2 tbl, 1 ex

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RU 2 649 368 C2

Authors

Kaspar Manuela

Shvager Katrin

Trachsel Evelin

Dates

2018-04-02—Published

2013-04-09—Filed

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