SYNERGISTIC BACTERIAL COMPOSITIONS AND METHODS FOR PREPARING AND USING THEM Russian patent published in 2020 - IPC A61K35/742 A61P1/00 

FIELD: medicine; gastroenterology.

SUBSTANCE: group of inventions can be used to reduce one type of pathogenic bacteria in the human gastrointestinal tract. Composition for inhibiting growth of at least one type of pathogenic bacteria and/or colonization by at least one type of pathogenic bacteria comprises a therapeutically effective amount of a population of bacterial spores, wherein the population of bacterial spores comprises at least a first type of recovered bacteria, a second type of recovered bacteria and a third type of recovered bacteria. First type, the second type and the third type are not identical, wherein the first type contains 16S nucleic acid sequence which is at least 97 % identical SEQ ID NO: 559, SEQ ID NO: 609 or SEQ ID NO: 886. Second type comprises 16S rDNA sequence which is at least 97 % identical to 16S rDNA sequence presented in the bacterium selected from Table 1. Third type comprises 16S rDNA sequence which is at least 97 % identical to 16S rDNA sequence presented in the bacterium selected from Table 1. Group of inventions also relates to a single standard dose, a pharmaceutical composition and use of the declared composition for treating dysbacteriosis, a reduction in C.difficile.

EFFECT: three-component bacterial composition containing bacteria, which contain 16S rDNA sequence Clostridium bolteae, Clostridium orbiscindens, Flavonifractor plautii, reduces pathogenic bacteria in the gastrointestinal tract, as well as synergistically inhibits Clostridium difficile.

13 cl, 24 ex, 22 tbl, 7 dwg