DEVELOPED BACTERIAL COMPOSITIONS Russian patent published in 2022 - IPC A61K35/741 A61K35/742 C12N1/20 A61P1/00 A61P31/04 

FIELD: medicine.

SUBSTANCE: group of inventions relates to a composition for the prevention or treatment of gastrointestinal tract dysbiosis in a subject who needs it, and its use. The composition for the prevention or treatment of gastrointestinal tract dysbiosis in a subject who needs it contains therapeutically effective number of viable bacteria of the first type and viable bacteria of the second type. At the same time, the first type contains 16S rDNA sequence that is at least 99% identical to 16S rDNA sequence given in SEQ ID NO: 85, SEQ ID NO: 86, SEQ ID NO: 87, SEQ ID NO: 88 or SEQ ID NO: 89. The second type has one or more features selected from a group consisting of: (i) producing histone deacetylase inhibitor (HDAC inhibitor), (ii) producing tryptophane metabolite, (iii) producing enzyme participating in producing secondary bile acid, and (iv) combinations thereof. A compound containing this composition, as well as a drug form with a single dose containing the composition or compound are also proposed.

EFFECT: specified composition or compound are used to prevent or treat gastrointestinal tract dysbiosis in a subject who needs it, or to treat or prevent the relapse of C. Difficile infection in a subject who needs it.

17 cl, 7 dwg, 11 tbl, 9 ex