PERORAL COMPOSITIONS CONTAINING ESTER 17- HYDROXYPROHESTERON, AND CORRESPONDING METHODS Russian patent published in 2018 - IPC A61K31/57 A61K9/20 A61K9/48 A61P15/06 

FIELD: pharmacology.

SUBSTANCE: bioavailable peroral dosage forms are proposed, containing 17-hydroxyprohesteron caproate in the form of particles with an average diameter of 50 micron or less, as well as corresponding methods. Said peroral dosage forms can be prepared for pregnancy maintenance and contain a therapeutically effective amount of 17-hydroxyprohesteron caproate and pharmaceutically acceptable carrier. At least 20 wt % of 17-hydroxyprohesteron ester dose escape from said peroral dosage forms during determination using a device for dissolution of 2nd type in accordance with USP in 900 ml of deionised water with 0.5% (wt/vol) of sodium lauryl sulphate at 50 rpm and 37°C in 60 minutes.

EFFECT: peroral form with high bioavailability.

54 cl, 3 dwg, 54 ex, 14 tbl