SUPPOSITORIES FOR TREATMENT OF MODERATE AND HIGH-INTENSITY PAIN SYNDROME Russian patent published in 2020 - IPC A61K9/02 A61K31/395 A61K47/44 A61K47/00 A61P25/04 

FIELD: medicine.

SUBSTANCE: invention refers to medicine and chemical-pharmaceutical industry, namely to suppositories for treating moderate and high-intensity pain syndrome. Pharmaceutical composition of rectal suppository contains 0.1–10 g/100 g of nefopam or its pharmaceutically acceptable salt, up to 90 % of particles of which have size from 0.5 to 90 mcm, at average median particle size of 31 to 90 mcm, to 100 g/100 g of a lipophilic base with pharmaceutically acceptable additives selected from a preserving, emulsifying and stabilizing agents or mixtures thereof.

EFFECT: invention provides prolongation of analgesic effect and shelf life of composition more than 2 years.

8 cl, 5 tbl, 5 ex