FIELD: organic chemistry.
SUBSTANCE: invention relates to a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt thereof, where X is CH; is L is a bond; R is a condensed cyclic group specified in claim 1, where each group represented by R is independently and optionally substituted with one, two, three, four or five R8; each R1 independently represents deuterium, F, Cl, Br or I; R2 is C1-6 alkyl or C3-6 cycloalkyl; each R8 independently represents deuterium, F, Cl, Br, I, -L1-C(=O)OR15, -L1-S(=O)tR16, -C(=O)N(R17)S(=O)2R16 or -C(=O)N(R17)-L3-S(=O)2OR15; each R15 independently represents H, deuterium or C1-6 alkyl; each R16 independently represents C1-6 alkyl; each R17 independently represents H or deuterium; each L1 independently represents a bond or C1-6 alkylene; each L3 independently represents a bond or C1-4 alkylene; n is 0, 1 or 2; each t is independently 0, 1 or 2. Invention also relates to a pharmaceutical composition based on a compound of formula (I).
EFFECT: obtaining novel heterocyclic compounds which are useful in the prevention or treatment of diseases mediated by FXR.
14 cl, 3 tbl, 37 ex
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Authors
Dates
2020-06-22—Published
2016-02-05—Filed