TRICYCLIC COMPOUNDS AND THEIR USE Russian patent published in 2020 - IPC C07D249/04 C07D261/08 C07D411/12 C07D413/12 C07D471/04 C07D491/44 C07D491/52 C07D491/147 C07D497/04 C07D498/04 C07D498/14 A61K31/4155 A61K31/4192 A61K31/422 A61K31/435 A61K31/4353 A61K31/4365 A61K31/4375 A61K31/4985 A61K31/5025 A61K31/519 A61K31/55 A61K31/553 A61P1/00 A61P11/00 A61P13/12 A61P15/10 A61P17/00 A61P29/00 A61P3/04 A61P3/06 A61P3/10 A61P31/20 A61P35/00 A61P43/00 A61P7/00 A61P9/00 

Abstract RU 2724100 C2

FIELD: organic chemistry.

SUBSTANCE: invention relates to a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt thereof, where X is CH; is L is a bond; R is a condensed cyclic group specified in claim 1, where each group represented by R is independently and optionally substituted with one, two, three, four or five R8; each R1 independently represents deuterium, F, Cl, Br or I; R2 is C1-6 alkyl or C3-6 cycloalkyl; each R8 independently represents deuterium, F, Cl, Br, I, -L1-C(=O)OR15, -L1-S(=O)tR16, -C(=O)N(R17)S(=O)2R16 or -C(=O)N(R17)-L3-S(=O)2OR15; each R15 independently represents H, deuterium or C1-6 alkyl; each R16 independently represents C1-6 alkyl; each R17 independently represents H or deuterium; each L1 independently represents a bond or C1-6 alkylene; each L3 independently represents a bond or C1-4 alkylene; n is 0, 1 or 2; each t is independently 0, 1 or 2. Invention also relates to a pharmaceutical composition based on a compound of formula (I).

EFFECT: obtaining novel heterocyclic compounds which are useful in the prevention or treatment of diseases mediated by FXR.

14 cl, 3 tbl, 37 ex

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RU 2 724 100 C2

Authors

Wang Xiaojun

Yang Xinye

Pan Shengqiang

Guo Rui

Wu Junwen

Zhang Yingjun

Cheng Changchung

Dates

2020-06-22Published

2016-02-05Filed