SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE Russian patent published in 2018 - IPC C07D401/14 C07D401/12 A61K31/4439 A61K31/444 A61K45/06 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention discloses novel compounds of substituted pyrazolones of formula (I) and pharmaceutically acceptable salts thereof that inhibit the activity of tyrosine kinase protein and modulate cellular activity, such as proliferation, differentiation, apoptosis, migration and invasion. In the compounds of formula (I), Q is -N(R^c)C(=O)R^d; W is CR⁷ or N; X is (C₆-C₁₀)aryl; each of Y and Z is independently (C₁-C₆)alkyl; each of R¹, R², R³, R⁴, R⁵, R⁶ and R⁷ is independently H, D, F or Cl; each of R^a, R^b and R^c is independently H; and R^d is (C₃-C₈) cycloalkyl, where (C₃-C₈)cycloalkyl is not substituted or optionally substituted with 1 or 2 substituents independently selected from D, F, Cl, Br, -CN, -OR^a-, -NR^aR^b and (C₁-C₆)alkyl. Invention also discloses pharmaceutically acceptable compositions comprising such compounds, and methods of using the compositions and compounds of formula (I) in the treatment of hyperproliferative disorders in mammals, particularly humans. .

EFFECT: treatment of hyperproliferative disorders in mammals, particularly in humans.

15 cl, 7 tbl, 30 ex