FIELD: chemistry.
SUBSTANCE: invention discloses novel compounds of substituted pyrazolones of formula (I) and pharmaceutically acceptable salts thereof that inhibit the activity of tyrosine kinase protein and modulate cellular activity, such as proliferation, differentiation, apoptosis, migration and invasion. In the compounds of formula (I), Q is -N(Rc)C(=O)Rd; W is CR7 or N; X is (C6-C10)aryl; each of Y and Z is independently (C1-C6)alkyl; each of R1, R2, R3, R4, R5, R6 and R7 is independently H, D, F or Cl; each of Ra, Rb and Rc is independently H; and Rd is (C3-C8) cycloalkyl, where (C3-C8)cycloalkyl is not substituted or optionally substituted with 1 or 2 substituents independently selected from D, F, Cl, Br, -CN, -ORa-, -NRaRb and (C1-C6)alkyl. Invention also discloses pharmaceutically acceptable compositions comprising such compounds, and methods of using the compositions and compounds of formula (I) in the treatment of hyperproliferative disorders in mammals, particularly humans. .
EFFECT: treatment of hyperproliferative disorders in mammals, particularly in humans.
15 cl, 7 tbl, 30 ex
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Authors
Dates
2018-04-18—Published
2013-07-19—Filed