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2 727 059

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IPC

A61K38/19(2006-01-01)

C07K14/525(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2019112838, 2019-04-26

(24)

Start date

2019-04-26

(22)

Actual filing date

2019-04-26

(45)

Published

2020-07-17

(72)

Inventor

Gasparyan Marine EduardovnaYagolovich Anna ValerevnaDolgikh Dmitrij AleksandrovichKirpichnikov Mikhail PetrovichArtykov Artem AleksandrovichKarmakova Tatyana AnatolevnaVorontsova Mariya Sergeevna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Bioorganicheskoj Khimii Im. Akademikov M.M. Shemyakina I Yu.A. Ovchinnikova Rossijskoj Akademii Nauk Ran)Obshchestvo S Ogranichennoj Otvetstvennostyu

METHOD OF SUPPRESSING GROWTH OF TUMOURS WITH GENETICALLY MODIFIED VERSION OF TRAIL CYTOKINE Russian patent published in 2020 - IPC A61K38/19 C07K14/525 A61P35/00

Abstract RU 2727059 C1

FIELD: biotechnology; medicine.

SUBSTANCE: invention refers to biotechnology and medicine, namely to oncology, and can be used for suppressing tumour growth in patients suffering colorectal cancer. Disclosed is a method for inhibiting the growth of colorectal cancer tumours in vivo by exposing a genetically modified version of the extracellular domain of TRAIL DR5-B recombinant protein, having an amino acid sequence as presented in SEQ ID NO. 1, on tumour-bearing animals, wherein DR5-B selectively binds to DR5 death receptor and causes death of tumour cells by apoptosis.

EFFECT: tumour growth inhibition reaches 41-46 % and is stably maintained at a relatively high level during 15^th to 30^th day after the beginning of the exposure.

1 cl, 5 dwg, 3 tbl, 3 ex

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RU 2 727 059 C1

Authors

Gasparyan Marine Eduardovna

Yagolovich Anna Valerevna

Dolgikh Dmitrij Aleksandrovich

Kirpichnikov Mikhail Petrovich

Artykov Artem Aleksandrovich

Karmakova Tatyana Anatolevna

Vorontsova Mariya Sergeevna

Dates

2020-07-17—Published

2019-04-26—Filed