FIELD: biotechnology; medicine.
SUBSTANCE: invention refers to biotechnology and medicine, namely to oncology, and can be used for suppressing tumour growth in patients suffering colorectal cancer. Disclosed is a method for inhibiting the growth of colorectal cancer tumours in vivo by exposing a genetically modified version of the extracellular domain of TRAIL DR5-B recombinant protein, having an amino acid sequence as presented in SEQ ID NO. 1, on tumour-bearing animals, wherein DR5-B selectively binds to DR5 death receptor and causes death of tumour cells by apoptosis.
EFFECT: tumour growth inhibition reaches 41-46 % and is stably maintained at a relatively high level during 15th to 30th day after the beginning of the exposure.
1 cl, 5 dwg, 3 tbl, 3 ex
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