RECOMBINANT ALBUMEN WITH ANTI-CANCER EFFECT, GENE CODING IT, AND APPLICATION THEREOF Russian patent published in 2008 - IPC C07K14/47 C12N15/12 C12N15/63 A61K38/16 

Abstract RU 2333221 C2

FIELD: chemistry.

SUBSTANCE: according to the invention, the recombinant albumen with anti-cancer effect is selected out of the group including 1) albumen with amino acid sequence presented in SEQ ID N0:2 indicated in the sequence list; 2) albumen with amino acid sequence homologous to the sequence presented in SEQ ID NO:2 by more than 90% and featuring the same effect as the albumen 1); 3) albumen obtained by replacement, deletion or addition of one or more residua to the amino acid sequence presented in SEQ ID NO:2 and featuring the same effect as the albumen 1). The invention also claims a gene coding the described recombinant albumen and its variants, expression vector containing the said gene, and cell line containing the said gene and intended for expression of the recombinant albumen. The recombinant albumen can be applied in obtaining cancer treatment medication. A medication including the aforesaid recombinant albumen as active component has strong selective effect on tumour cells and does not cause apoptosis of normal tissue cells.

EFFECT: developed substance for obtaining cancer treating medication.

14 cl, 16 dwg, 7 tbl, 3 ex

Similar patents RU2333221C2

Title Year Author Number
NEW ANTI-DR5 ANTIBODY 2011
  • Okhtsuka Tosiaki
  • Takizava Takesi
  • Oguni Akiko
  • Matsuoka Tatsudzi
  • Josida Khiroko
  • Matsui Yumi
RU2644678C1
NEW ANTI-DR5 ANTIBODY 2011
  • Okhtsuka Tosiaki
  • Takizava Takesi
  • Oguni Akiko
  • Matsuoka Tatsudzi
  • Josida Khiroko
  • Matsui Yumi
RU2590711C2
ANTIBODIES RECOGNISING CARBOHYDRATE CONTAINING EPITOPE ON CD-43 AND CEA EXPRESSED ON CANCER CELLS, AND METHODS OF USING SUCH 2007
  • Lin Rong-Khva
  • Lin Leeven
  • Lin Shikh-Jao
  • Li Shu-Khua
RU2461572C2
ANTIBODIES RECOGNIZING CARBOHYDRATE-CONTAINING EPITOPE ON CD-43 AND CEA EXPRESSED ON CANCER CELLS AND METHODS OF APPLICATION 2012
  • Lin Rong-Khva
  • Lin Leeven
  • Lin Shikh-Jao
  • Li Shu-Khua
RU2616868C2
SINGLE-CHAIN TRAIL-RECEPTOR AGONIST PROTEINS 2015
  • Hill, Oliver
  • Gieffers, Christian
  • Thiemann, Meinolf
  • Phillips, Darren, C.
  • Lappe, Susan, E.
  • Buchanan, Fritz, G.
RU2699285C2
INTENSIFICATION OF ACTION OF ANTICANCER AGENTS 2006
  • Belivo Rishar
  • Demele Mishel'
  • She Kristian
  • Redzhina Ehntoni
RU2422143C2
HUMANIZED MONOCLONAL ANTIBODY SPECIFIC TO SYNDECAN-1 2015
RU2611685C2
ANTIBODY SELECTIVE TO RECEPTOR APOPTOSIS-INDUCING LIGAND AND ASSOCIATED WITH TUMOR NECROSIS FACTOR AND ITS USING 2002
  • Chzhou Tun
  • Kimberli Robert P.
  • Kupman Uil'Jam Dzh.
  • Lobuglio Al'Bert F.
  • Bukhsbaum Donal'D Dzh.
RU2313537C2
DR5 ANTIBODIES AND USE THEREOF 2006
  • Adams Kamellija V.
RU2458072C2
THERAPEUTIC ANTIBODIES BINDING TO LEWIS B AND LEWIS Y BIANTENNA ANTIGENS 2019
  • Chan, Tun-Syuan
  • Yan, Mej-Chun
  • Liu, Lian-Jirn
  • Tin, Dzherri
  • Chan, Shu-En
  • Chen, En-In
  • Lin, Yuj-Yuj
  • Tan, Shu-Lun
RU2803097C2

RU 2 333 221 C2

Authors

Chzhu Bin

Dates

2008-09-10Published

2003-11-03Filed