METHOD FOR INCREASING EFFECTIVENESS OF IMMUNE CHECKPOINT INHIBITORS USING THERAPEUTIC COMPOSITION BASED ON INDOLE DERIVATIVES AND PROBIOTIC Russian patent published in 2024 - IPC A61K31/404 A61K35/745 A61K35/747 A61K45/06 A61P35/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention is aimed at increasing the anti-tumor efficacy of immunotherapy with programmed cell death receptor 1 (PD-1) inhibitors. Method of increasing the effectiveness of PD-1 inhibitors involves administering a low-molecular compound indole-3-propionate and a probiotic based on microorganism strains Lacticaseibacillus paracasei subsp. paracasei 29n_21 (registration number VKM B-3711D) and Bifidobacterium longum subsp. longum 202/21 (registration number VKM B-3717D), wherein indole-3-propionate and probiotic agent are not mixed before introduction. Indole-3-propionate is administered in the form of a solution containing up to 4% ethoxylated castor oil and suitable for oral or intravenous administration, wherein the dose of indole-3-propionate in the form of a solution for single oral and intravenous administration should not exceed 400 mg/kg, and for multiple administration, the total course dose should not exceed 400 mg/kg. One dose of the probiotic agent contains lacto-N-biose, chitosan, 7×10⁷ CFU Lactobacillus paracasei subsp. paracasei and 8×10⁷ CFU Bifidobacterium longum subsp. Longum.

EFFECT: invention provides higher anticancer efficacy of the immunotherapeutic regimen.

4 cl, 4 dwg, 9 tbl, 5 ex