HETEROCYCLIC COMPOUNDS FOR TREATING DISEASE Russian patent published in 2020 - IPC C07D471/04 A61K31/4245 A61K31/41 A61P1/04 A61P25/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: present invention refers to a compound of general formula (I) and its pharmaceutically acceptable salt, which can find application in modulation of sphingosine-1-phosphate receptors (S1P). In formula (I) X₁, X₂, X₃ and X₄ are CR₁; is selected from and ; Z is -O- or -OCH₂-; each R₁ is independently selected from a group consisting of hydrogen, halogen and C₁-C₆ alkyl substituted by halogen; each R₂ is independently selected from the group consisting of halogen and C₁-C₆ alkyl substituted by halogen; R₃ is selected from the group consisting of hydrogen and C₁-C₆ alkyl; n equals 0–4 and p equals 0 or 1. Present invention also relates to a pharmaceutical composition for modulating sphingosine-1-phosphate (S1P) receptor activity, comprising a pharmaceutically acceptable diluent, excipient or binder and compound of formula (I) or its pharmaceutically acceptable salt. Described also is use of compounds of formula (I) and their pharmaceutically acceptable salts for treating a disease, disorder or condition, where the disease, disorder or condition is selected from multiple sclerosis, ulcerative colitis and Crohn's disease.

EFFECT: heterocyclic compounds for treating a disease are disclosed.

21 cl, 2 dwg, 1 tbl, 20 ex