INHIBITION OF CREB-BINDING PROTEIN (CBP) Russian patent published in 2023 - IPC C07D471/04 A61K31/4745 A61P35/00 

FIELD: pharmaceutical chemistry.

SUBSTANCE: group of inventions includes a compound of formula (I), its pharmaceutically acceptable salts, an enantiomer, a stereoisomer, specific compounds and their pharmaceutically acceptable salts given in the claims, as well as a pharmaceutical composition. In the formula (I) R¹ is -OR⁵; R⁵ is -C₁-C₆alkyl; R⁶ is phenyl optionally substituted with one or more R¹⁰; R¹⁰ is at each occurrence independently -C₁-C₆alkyl, halogen, -OC₁-C₆alkyl, or -OC₃-C₆cycloalkyl, where each alkyl or cycloalkyl is optionally substituted with one or more -R¹²; any two R¹⁰, if present on non-adjacent atoms, may be combined to form a bridged C₃-C₈cycloalkyl; or any two R¹⁰, if present on adjacent atoms, may be combined to form either C₃-C₈cycloalkyl or heterocyclyl or heteroaryl selected from dihydrofuranyl, furanyl, oxazolyl, methyloxazolyl, pyrrolyl, N-methylpyrrolyl and pyrazolyl, and R¹² is at each occurrence independently either -C₁-C₆alkyl, -OH, or halo.

EFFECT: imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid derivatives having inhibitory activity against CREB-binding protein (CBP) and/or p300.

27 cl, 1 dwg, 5 ex